Limb-girdle muscular dystrophy (LGMD) is a group of rare muscular dystrophies characterized by progressive muscle wasting affecting the hip and shoulder muscles. It is genetically heterogeneous, with at least 20 different types. Most forms are inherited in an autosomal recessive manner, while some are autosomal dominant. Symptoms include weakness in proximal muscles, leading to difficulty walking, running, and eventually requiring wheelchair assistance. Postural changes, joint stiffness, and heart and respiratory issues may also occur. Intelligence is typically unaffected, but developmental delays have been reported in rare cases. LGMD has no known cure or treatment.