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Pick Disease of Brain (PIDB)
Alias:
Pick Disease
|
Pick Disease of the Brain
|
Lobar Atrophy of Brain
|
Dementia with Lobar Atrophy and Neuronal Cytoplasmic Inclusions
|
Pick's Disease
|
Dementia in Pick's Disease
|
Picks Disease
|
Pidb
Basic Information
Medical Symptom
Gene & Mutation
Related Drugs
Disease Model
References Literature
Pick disease is a form of frontotemporal dementia characterized by the presence of Pick bodies and Pick cells in the brain. It is associated with behavioral changes, language difficulties, and memory loss. The disease is pathologically defined by severe atrophy, neuronal loss, and the presence of tau-positive inclusions. Frontotemporal dementia generally presents as a behavioral or language disorder with gradual onset, affecting both men and women equally. There is currently no cure for Pick disease, and treatment options are limited to off-label drugs and behavioral interventions. Brain atrophy, specifically in the frontal and temporal lobes, is a common feature of Pick disease and other brain disorders.
Related ID:
Basic Information
Inheritance | Age of Onset | Prevalence | Related Genes | Related Mouse Models | Reference | MALACARDS |
|---|---|---|---|---|---|---|
AD Autosomal dominant | Unknown | -- | 47 | 797 | 234 |
Medical Symptom
Phenotype Information Associated with the Current Disease:
Categorization: Anatomical classification of the disease manifestations.
HPO Frequency/Orphanet Frequency: Indicates the probability of the manifestation occurring in the current disease, allowing sorting by probability.
HPO Source Accession: Links to HPO for detailed manifestation information.
Data Source: HPO, Orphanet
Gene & Mutation
Genes and Mutations Associated with the Current Disease:
Function: Primary biological roles of the genes.
Score: Indicates the strength of the association between the disease and the gene, with higher scores reflecting stronger associations.
Count: Number of mutations associated with the disease-gene pair. The number in parentheses represents the total data points linked to the same ClinVar ID. Clicking the number reveals mutation details.
Data Source: Clinvar
Related Drugs
Drugs Related to the Current Gene, Displaying CAS Number, Status and Phase.
Data Source: Clinical Trials
Related Mouse Models
Mouse Models Related to the Current Gene. Click on the model name to view detailed information.
Data Source: MGI, Cyagen
References Literature
Most Relevant Literature for the Current Gene, Filterable by Year, Article Type, and Sortable by Impact Factor.
Data Source: UniProt, PubMed