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Parkinson Disease, Late-Onset (PD)
Alias:
Late Onset Parkinson's Disease
|
Late Onset Parkinson Disease
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Park
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Pd
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Autosomal Dominant Late-Onset Parkinson Disease
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Hereditary Late-Onset Parkinson Disease
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Parkinson Disease
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Lopd
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Parkinson Disease, Late-Onset, Susceptibility to, Multifactorial
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Parkinson Disease, Age of Onset, Modifier, Multifactorial
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Parkinson Disease, Susceptibility to, Multifactorial
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Hereditary Late Onset Parkinson Disease
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Late-Onset Parkinson Disease
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Idiopathic Parkinson Disease
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Lewy Body Parkinson Disease
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Primary Parkinsonism
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Paralysis Agitans
Basic Information
Medical Symptom
Gene & Mutation
Related Drugs
Disease Model
References Literature
Parkinson disease (PD) is a neurodegenerative disorder affecting about 1% of individuals over 50 years old. Late-onset Parkinson disease (LOPD) is a form of PD with onset after 50 years, presenting with tremor, gait issues, bradykinesia, rigidity, and cramps. Patients have a low risk of non-motor symptoms. The disease is characterized by bradykinesia, tremor, rigidity, and postural instability, with additional features like dysautonomia, dystonic cramps, and dementia. Pathologically, PD involves the loss of dopaminergic neurons and Lewy bodies in the brain. The majority of cases are sporadic, but some have a familial history. Familial forms start earlier and have atypical features. Late-onset PD typically manifests after 60 years of age.
Related ID:
Basic Information
Inheritance | Age of Onset | Prevalence | Related Genes | Related Mouse Models | Reference | MALACARDS |
|---|---|---|---|---|---|---|
AD Autosomal dominant Ot Other | Adult | -- | 107 | 707 | 209 |
Medical Symptom
Phenotype Information Associated with the Current Disease:
Categorization: Anatomical classification of the disease manifestations.
HPO Frequency/Orphanet Frequency: Indicates the probability of the manifestation occurring in the current disease, allowing sorting by probability.
HPO Source Accession: Links to HPO for detailed manifestation information.
Data Source: HPO, Orphanet
Gene & Mutation
Genes and Mutations Associated with the Current Disease:
Function: Primary biological roles of the genes.
Score: Indicates the strength of the association between the disease and the gene, with higher scores reflecting stronger associations.
Count: Number of mutations associated with the disease-gene pair. The number in parentheses represents the total data points linked to the same ClinVar ID. Clicking the number reveals mutation details.
Data Source: Clinvar
Related Drugs
Drugs Related to the Current Gene, Displaying CAS Number, Status and Phase.
Data Source: Clinical Trials
Related Mouse Models
Mouse Models Related to the Current Gene. Click on the model name to view detailed information.
Data Source: MGI, Cyagen
References Literature
Most Relevant Literature for the Current Gene, Filterable by Year, Article Type, and Sortable by Impact Factor.
Data Source: UniProt, PubMed