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Mouse
Gpx1 - glutathione peroxidase 1
Alias:
CGPx
|
GPx-1
|
GSHPx-1
|
Gpx
Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Related ID:
Basic Information
Gene Type | NCBI | Transcripts | Exons | Length | MW (kDa) | Related Mouse Models | Reference |
|---|---|---|---|---|---|---|---|
Protein-coding | 3 | 2 | 1263 bp | 22.33 | 8 | 18 |
Gpx1 Genetics information (+)
GRCm39
Sequence Homology
Compare the differences in orthologous genes between rat, mouse, and human regarding the following aspects:
Gene Length: Chromosomal location and the number of base pairs within the gene.
Transcript Length: MANE (Matched Annotation from NCBI and EMBL-EBI) transcript ID and its sequence length.
Protein Length: MANE protein ID and its length information.
Exon count: The count of exons in the MANE transcript of the gene.
CDS homology: Comparison of CDS splice sequence similarity encoding MANE proteins, with human, mouse, or rat sequence as the baseline (100% reference).
Protein homology: Comparison of amino acid sequence similarity of MANE proteins, using human, mouse, or rat sequence as the baseline (100% reference).
Data Sources: NCBI, ALLIANCE
Transcripts & Proteins
Overview of Current Gene Transcripts, Switchable Between Table and Graph Views:
Table: Provides a summary of transcript sequence length, exon count, CDS (Coding Sequence) length, associated protein sequence ID, protein sequence length, and other relevant information.
Tile: Offers a visual representation of introns, exons, UTRs (Untranslated Regions), and CDS (Coding Sequence).
MANE Select: The primary 1:1 matched representative transcript for human genes.
MANE Plus Clinical: Additional transcripts required for clinical interpretation.
RefSeq Select: The best representative transcript for non-human species (e.g., Mouse) or other RefSeq genes.
Data Source: NCBI
Gene Expression
Current RNA expression levels of the gene across various tissues and cell types, allowing users to sort by tissue type, specific expression values, or alphabetical order.
Data Source: NCBI
Interactions
Interacting Genes of the Current Gene, Including:
Acting, Target: Distinguishes the upstream interacting protein from the downstream target protein in the interaction chain.
Regulation: Four types of regulation.
[
] Up-Regulates.
] Up-Regulates.[
] Down-Regulates.
] Down-Regulates.[
] Form Complex.
] Form Complex.[
] Unknown.
] Unknown.Solid lines indicate direct interactions, dashed lines represent indirect ones.
Acting, Target: Distinguishes the upstream interacting protein from the downstream target protein in the interaction chain.
Details: Indicates changes in protein quantity or activity post-interaction.
Mechanism: Elucidates functional transitions resulting from the interaction.
Residues: Specifies the particular amino acid residues involved in the interaction, along with the studied species, tissue, or cell.
References: Summarizes and displays relevant interaction studies, their publications, and overviews, with indications of the studied species, tissue, or cell.
Score: Quantifies the tightness of the interaction through a scoring system. Higher scores imply stronger associations.
Data Source: Signor, PubMed
Related Mouse Models
Mouse Models Related to the Current Gene. Click on the model name to view detailed information.
Data Source: MGI, Cyagen
References Literature
Most Relevant Literature for the Current Gene, Filterable by Year, Article Type, and Sortable by Impact Factor.
Data Source: UniProt, PubMed