Learn
EN
中文
Mouse
Pdgfra - platelet derived growth factor receptor, alpha polypeptide
Alias:
CD140a
|
Pdgfr-2
Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]
Related ID:
Basic Information
Gene Type | NCBI | Transcripts | Exons | Length | MW (kDa) | Related Mouse Models | Reference |
|---|---|---|---|---|---|---|---|
Protein-coding | 8 | 27 | 46880 bp | 122.68 | 33 | 14 |
Pdgfra Genetics information (+)
GRCm39
Sequence Homology
Compare the differences in orthologous genes between rat, mouse, and human regarding the following aspects:
Gene Length: Chromosomal location and the number of base pairs within the gene.
Transcript Length: MANE (Matched Annotation from NCBI and EMBL-EBI) transcript ID and its sequence length.
Protein Length: MANE protein ID and its length information.
Exon count: The count of exons in the MANE transcript of the gene.
CDS homology: Comparison of CDS splice sequence similarity encoding MANE proteins, with human, mouse, or rat sequence as the baseline (100% reference).
Protein homology: Comparison of amino acid sequence similarity of MANE proteins, using human, mouse, or rat sequence as the baseline (100% reference).
Data Sources: NCBI, ALLIANCE
Transcripts & Proteins
Overview of Current Gene Transcripts, Switchable Between Table and Graph Views:
Table: Provides a summary of transcript sequence length, exon count, CDS (Coding Sequence) length, associated protein sequence ID, protein sequence length, and other relevant information.
Tile: Offers a visual representation of introns, exons, UTRs (Untranslated Regions), and CDS (Coding Sequence).
MANE Select: The primary 1:1 matched representative transcript for human genes.
MANE Plus Clinical: Additional transcripts required for clinical interpretation.
RefSeq Select: The best representative transcript for non-human species (e.g., Mouse) or other RefSeq genes.
Data Source: NCBI
Gene Expression
Current RNA expression levels of the gene across various tissues and cell types, allowing users to sort by tissue type, specific expression values, or alphabetical order.
Data Source: NCBI
Interactions
Interacting Genes of the Current Gene, Including:
Acting, Target: Distinguishes the upstream interacting protein from the downstream target protein in the interaction chain.
Regulation: Four types of regulation.
[
] Up-Regulates.
] Up-Regulates.[
] Down-Regulates.
] Down-Regulates.[
] Form Complex.
] Form Complex.[
] Unknown.
] Unknown.Solid lines indicate direct interactions, dashed lines represent indirect ones.
Acting, Target: Distinguishes the upstream interacting protein from the downstream target protein in the interaction chain.
Details: Indicates changes in protein quantity or activity post-interaction.
Mechanism: Elucidates functional transitions resulting from the interaction.
Residues: Specifies the particular amino acid residues involved in the interaction, along with the studied species, tissue, or cell.
References: Summarizes and displays relevant interaction studies, their publications, and overviews, with indications of the studied species, tissue, or cell.
Score: Quantifies the tightness of the interaction through a scoring system. Higher scores imply stronger associations.
Data Source: Signor, PubMed
Related Mouse Models
Mouse Models Related to the Current Gene. Click on the model name to view detailed information.
Data Source: MGI, Cyagen
References Literature
Most Relevant Literature for the Current Gene, Filterable by Year, Article Type, and Sortable by Impact Factor.
Data Source: UniProt, PubMed